Simulates maternal plasma / effect-site drug concentration during general anaesthesia and estimates the fraction reaching the neonate at a chosen induction-to-delivery time, using published population pharmacokinetic models and reported umbilical vein:maternal ratios.
Created by Claude (AI). AI makes mistakes — use clinical judgement. This tool estimates, it does not measure. Outputs are approximations built from published population models and literature-derived placental-transfer ratios, several of which are simplified or could not be independently re-verified against primary sources in this session (see “Models & references” below). By accessing or using this calculator you assume responsibility for its use; it is not validated for, and must not replace, clinical judgement or a decision-support device.
Maternal parameters
Used to individualise each pharmacokinetic model
Anaesthetic drugs
Time 0 = induction. Add each drug you plan to give.
Delivery time
Induction → delivery (I–D) interval
10.0min after induction
Simulated exposure
Maternal (plasma / effect-site) Estimated neonatal (umbilical vein)┊ delivery time